When the Fantastic Four go into combat, they have specialist uniforms required for their mutation. Throughout the 2005 film and the 2007 sequel, there has been many different re-designs.
The uniforms were originally designed by Victor Von Doom for their project into space. The synthetics acted as a second layer of skin, therefore adapting to the body's individual needs.
When the cosmic storm hits, their uniforms became exposed, therefore adapting to the individual's mutation. Reed's stretches and expands as his body does, Sue's turns invisible along with her skin, and Johnny's is fireproof. These would prove quickly indispensable, due to the fact the Fantastic Four's more dangerous powers (such as Johnny's) constantly destroyed their normal clothing. They would begin to always wear the skintight suits under other clothes.
Reed Richards later learnt that the synthetics in the uniform adapted to their needs, so he adapted the designs and produced a uniform for each member of the team. Ben Grimm, however, was unable to wear the uniform due to his increase in size and mass, so only wore half of the uniform.
The team wear the same uniform as before. Also Johnny Storm endorses a new uniform with a lot of promotions by leading retailers. However, none were taken on, subsequently never producing or using the uniform.